Aluminum Zirconium Pentachlorohydrex Gly
Aluminum zirconium pentachlorohydrex glycine
- Role
- Temporarily reduces sweat release in the treated area.
- Catalog formulas
- 0
- Type
- Active
- Verified
- 09.11.2026
What does this ingredient do in an antiperspirant?
According to CosIng, it is the reaction product of aluminum zirconium pentachlorohydrate (Al8Zr(OH)23Cl5·xH2O) with the amino acid glycine; its functions are antiperspirant, astringent and deodorant. COSMILE Europe explains that antiperspirants based on aluminum salts regulate sweat release, whereas deodorants suppress or mask odor.
Part of a system, not a label in isolation
It is found in sticks and other non-aerosol forms. The FDA allows this active at up to 20% (calculated on an anhydrous basis) and only in a non-aerosol dosage form (monograph M019, § M019.10(n)); in the EU, aluminum-zirconium complexes are likewise banned from aerosol dispensers.
In the EU it is permitted only in antiperspirants: up to 20% as the anhydrous complex and up to 5.4% as zirconium; the ratio of aluminum to zirconium atoms must be between 2 and 10, and of (Al + Zr) to chlorine atoms between 0.9 and 2.1. The label must carry the warning "do not apply to irritated or damaged skin"; the SCCS considers aluminum compounds safe in cosmetics within the limits assessed in opinion SCCS/1662/23.
Under FDA rules, the label must say not to use it on broken skin, to stop use if a rash or irritation occurs, and to ask a doctor before use in case of kidney disease.
It is not the same as Aluminum Zirconium Pentachlorohydrate: the FDA lists the pentachlorohydrate without glycine as a separate entry (§ M019.10(m)). It differs from Tetrachlorohydrex Gly and Octachlorohydrex Gly in the ratio of aluminum, zirconium and chlorine atoms set by the US Pharmacopeia (USP–NF).
Products containing Aluminum Zirconium Pentachlorohydrex Gly
Links are based on the complete published INCI list for the exact product version.
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Sources
The conclusions apply to the stated conditions and jurisdictions, not automatically to every concentration or product.
- EU CosIng: Aluminum Zirconium Pentachlorohydrex Gly Supports: function, substance identity, restrictions
- FDA OTC Monograph M019 Supports: list of active ingredients, permitted concentration, dosage form, label warnings
- Regulation (EC) 1223/2009, Annex III, entry 50 Supports: permitted concentration, restrictions, label warnings
- SCCS/1662/23: safety of aluminum in cosmetic products Supports: safety assessment, conditions of use
- COSMILE Europe (CosIng data): Aluminum Zirconium Pentachlorohydrex Gly Supports: function, mode of action